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3.7 Conclusion 3.7.1 Implications for practice It can be concluded that DCM manifests as severe inflammation in the heart muscles and correlates with the increases in the pro-inflammatory cytokines including HMGB1 and the immune mediators which require their inhibition or at least partial suppression of those parameters by manipulating the genetic and epigenetic factors

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J Biol Chem 286(30):2651626523 Gupta RK, Arany Z, Seale P, Mepani RJ, Ye L, Conroe HM, Spiegelman BM (2010) Transcriptional control of preadipocyte determination by Zfp423

According to this theory, the accumulation of iron from erythrocytes evokes oxidative stress [Citation13]