John Wilding, professor of medicine in the Department of Cardiovascular and Metabolic Medicine at the University of Liverpool, said this was unsurprising, adding: Obesity is a chronic disease that usually relapses when treatment is stopped. Tricia Tan, professor of metabolic medicine, diabetes and endocrinology at Imperial College London/Imperial College Healthcare NHS Trust, said: There is increasing evidence that structured exercise is important to prevent weight regain after cessation of weight-loss drugs, but noted that this was not discussed in the study
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Although aggressive weight loss improves glycemic and cardiovascular outcomes, it may increase transient gallstone formation
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ER stress refers to the activation of ER responses, such as the unfolded protein response (UPR) and apoptosis signaling pathway, through the accumulation of misfolded and unfolded proteins and the disorder of calcium balance after various stress agents are applied to cells