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Men should maintain adequate nutrition and hydration during weight loss, as severe caloric restriction (even from effective appetite suppression) can theoretically stress reproductive hormones

These arent unique to retatrutide, but they underline why close medical supervision is essential

Although profound insulin deficiency is the hallmark of type 1 diabetes, some adults with type 1 diabetes maintain some insulin secretion for years after diagnosis and may not require insulin treatment at diagnosis [5], leading to diagnostic uncertainty about the type of diabetes and its management

14 ACC=American College of Cardiology