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As chronic PE induces tissue changes that go beyond skeletal muscle tissue (e.g., increase in mitochondria in adipose tissue), it is plausible that changes such as improvement in mitochondrial metabolism (improves their structure and function) in the epidermis also could occur in response to physical training practice (see Figure 6)

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For MIA mice, a continuous ICV infusion of 2.5 g per day was administered over a seven-day period

Treatment - if treatment is even necessary - will depend entirely on what is found