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Recent studies have demonstrated that spermidine effectively inhibits the phosphorylation of signal transducer and activator of transcription 1 (STAT1) by upregulating protein tyrosine phosphatase non-receptor 2 (PTPN2), thereby promoting macrophage polarization toward the anti-inflammatory M2 phenotype and suppressing excessive inflammatory responses

NAD+ also functions as an essential co-substrate for many key enzymes that regulate gene expression

Low stomach acid can lead to an increase in intra-abdominal pressure, which can cause the lower esophageal sphincter to open

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The remaining third of the EDTA-treated plasma was stored at 4 o C without prior deproteinization and was deproteinized immediately prior to analysis