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(Aronne et al., 2025, NEJM, PMID 40353578.) That number reset the fields expectations for what a single drug could do

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Furthermore, when we examined the expression of genes encoding enzymes that act as metabolic gatekeepers in CD4 + T cells, we found a BHD-induced upregulation of Cpt1 (fatty acid oxidation), Got1 (amino acid metabolism), Ndufs8 (OXPHOS), Sdha , Sdhb , Sdhc (TCA cycle) and Txnrd1 (redox balance) (Fig