(Source) When this enzyme is present in great concentration within fat cells and is highly expressed, obesity is inevitable: In the study by Kannt and colleagues, NNMT expression is increased ~2-fold in subcutaneous and omental adipose tissue of type 2 diabetic subjects (men and women), compared to healthy controls Importantly, interventions that increase insulin sensitivity, such as exercise and bariatric surgery, also decreased expression of NNMT in adipose tissue For this reason alone, scientists have been interested in every possible method for inhibiting NNMT expression: We report that NNMT expression is increased in [white adipose tissue (WAT)] and liver of obese and diabetic mice
The safety was preliminarily verified: The acute toxicity test showed that a single subcutaneous injection of AOD 9604 (50 mg/kg) did not cause death or obvious toxic reactions in mice
If vitamin B12 deficiency is not treated with a vitamin B12 supplement, then anemia, intestinal problems, and irreversible nerve damage may occur
Then, smaller doses keep those levels up
What is vitamin B12 (cyanocobalamin) used for