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Diabetes Metab 49(5):101470 Mansur RB et al (2017) Liraglutide promotes improvements in objective measures of cognitive dysfunction in individuals with mood disorders: a pilot, open-label study

Tirzepatide is a dual GIP/GLP-1 receptor agonist made by Eli Lilly, given as a once-weekly subcutaneous injection

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community and clinical sources describe dermatological monitoring for these changes, especially with long-term use Injection site darkening localized hyperpigmentation Mood changes irritability reported by some during loading Managing nausea: community sources commonly describe beginning at 100-250 mcg, injecting before bed on an empty stomach, using anti-nausea medication (ondansetron) when needed, and escalating the dose gradually