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Because the majority of the -cells do not express GLP-1R, and also because GLP-1 inhibits glucagon secretion even in T1D patients with low insulin pancreatic reserve, the mechanism by which GLP-1 decreases glucagon secretion is still a matter of debate [15]

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Additionally, tirzepatide mimics two hormones produced in the body in addition to being a GLP-1 agonist, it also activates the glucose-dependent insulinotropic polypeptide (GIP) hormone receptors

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