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N Engl J Med 2016;375: 311-22

Mechanistic insight from the crystal structure of mitochondrial complex I

however, shared decision-making between the primary care physician and patient is important for improving patient outcomes

For patients also taking insulin or sulfonylureas, it's important to note that hypoglycaemia can cause symptoms including sweating and shakiness, which might be confused with feeling cold

Water-soluble vitamin deficiencies are less common in well-nourished populations but can occur with alcohol use disorder, malabsorption conditions, strict veganism (particularly for B12), or prolonged poor dietary intake