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These factors contributed strongly to development of the most commercially successful GLP-1 RA product, Victoza, earning last year ~$3.4 billion and controlling over 50% of the overall GLP-1 RA market

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These medications work by mimicking the incretin hormones that the body naturally produces

Gut incretin hormones in identical twins discordant for non-insulin-dependent diabetes mellitus (NIDDM)evidence for decreased glucagon-like peptide 1 secretion during oral glucose ingestion in NIDDM twins

GLP-1s help by: Decreasing appetite Improving insulin sensitivity Reducing the delivery of free fatty acids to the liver Improving insulin resistance Lowering inflammation Reducing oxidative stress