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doi: 10.3389/fmicb.2022.900021 140 LeeA-LChenB-CMouC-HSunM-FYenH-R

Aging Cell 25 , e70318 (2026)

DAG is a potent activator of these PKC isoforms and the membrane-associated PKCs will phosphorylate the intracellular portion of the insulin receptor on serine residues which results in impairment of insulin receptor interaction with downstream signaling proteins including insulin receptor substrate 1 (IRS1) and IRS2

To test whether LKO mice retained this protective phenotype under more stringent conditions, we challenged them with 600 mg/kg APAP, a non-regenerating dose that causes sustained hepatocellular injury, impaired regeneration, and poor survival outcomes [29]

& Greenwood, L