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Outside those exceptions, there are no large-scale, long-term human safety trials confirming outcomes for perimenopausal women, which means clinical supervision is not optional

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Klein, K

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These actions cause a decrease in circulating serotonin at the chemoreceptor trigger zone, reducing the symptoms of nausea and vomiting in affected patients.107,108 Ondansetron is metabolized in the liver by CYP3A4, CYP1A2, and CYP2D6, and excreted by the kidneys.109 Numerous data show the efficacy of this agent in nausea and vomiting induced by chemotherapy and in the postoperative period.110,111 The expert committee of the American Neurogastroenterology and Motility Society and the Cyclic Vomiting Syndrome Association recommend ondansetron as a first-line agent for aborting an episode of CVS

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In addition, glutamine has been confirmed to be a major nutrient source for oxidative metabolism in some cancer cell lines 10,11,12 , and specific genetic interference with glutaminase (GLS) inhibits tumor cell growth 13

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38 ZhangPOmanskaAAnder BradleyPGandal MichaelJStamovaBSchumann CynthiaM

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