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The GLO-1 gene is located on human chromosome 6p21.2 ( The Warburg effect, a hallmark of cancer metabolism characterized by increased glycolysis ( Studies employing cell culture models, patient samples, and tissue microarray analysis have previously shown that GLO-1 is overexpressed during melanoma progression ( Considering the potential tumorigenic role of GLO-1, we analyzed its pathological and prognostic value in a range of malignancies

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128 In detail, a population study across 441 adults described that diabetic patients have a three times higher ratio of MMP-8/TIMP-1 and twice as high concentration of MMP-8, as a consequence of the elevated inflammatory status in these patients