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Depression and stress: Todays research suggests that the underlying cause of most depression is inflammation

Eventually, in response to excessive glucose stress, the -cells fail to produce sufficient insulin, leading to -cell dysfunction and subsequent onset of a severe form of T2DM (Tahrani et al., 2016

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The long-term administration of lixisenatide has been shown to decrease NHE3 activity in overweight T2D patients

Participants Adult patients with diabetes who were newly prescribed add-on non-insulin glucose-lowering agents and were on metformin between 2005-2020