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Primary human hepatocytes (PHH) were obtained from BioIVT (donors IAN, IPH, GID) and from Lonza (donors HUM4108, HUM4055B, HUM4229, HUM181501B)

S100A8 lacks the ability of Ca 2+ -binding in the N-terminal EF-hand motif, due to the absence of Ca 2+ -coordination necessary amino acid residues

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Importance of Consultation with Healthcare Professionals: Before using any skin whitening tablets or supplements, it's crucial to consult with a healthcare professional, such as a dermatologist or a doctor