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In 2014, Mancias substantiated that NCOA4 is a distinct receptor for ferritin autophagy via proteomic analyses, thereby establishing a connection between cellular autophagy and ferroptosis ( Research has demonstrated that the augmentation of NCOA4-mediated autophagic degradation of ferritin, commonly referred to as ferroautophagy, induces the accumulation of labile iron pool (LIP) and reactive oxygen species (ROS), ultimately leading to the occurrence of cell ferroptosis ( Research has substantiated that the expression of CACNA1G-AS1 is considerably elevated in ovarian cancer tissues and induces upregulation of FTH1 via IGF2BP1-mediated m6A methylation

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Treatment for vitamin B12 deficiency typically involves vitamin B12 supplementation, either through injections or oral supplements

Schormans AL, Typlt M, Allman BL