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Some reports exist that link mitochondrial ROS production to hypertension

4 Key Laboratory of CNS Regeneration, Ministry of Education, Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou, China

For instance, TNF has been shown to induce the release of mitochondrial DNA (mtDNA), which then activates cGAS-STING-mediated IFN responses, contributing to the progression of arthritis

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Protein turnover releases - N -trimethyllysine, which is hydroxylated by - N -trimethyllysine hydroxylase in a reaction requiring Fe 2+ and ascorbate, producing -hydroxy-- N -trimethyllysine