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Vitamin B12 is essential for neurologic function, red blood cell creation, and DNA synthesis and is a coenzyme for three primary biochemical conversions: homocysteine to methionine, 5-methyltetrahydrofolate to tetrahydrofolate, and methylmalonic acid to succinyl coenzyme A [1, 2]

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In addition to that, the rat sarcoma virus (Ras) signaling pathway has also been connected in up-regulation of VEGF secretion [58]