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When phentermine and topiramate were co-administered to rats at doses of 3.75 and 25 mg/kg, respectively [approximately 2 times the maximum recommended human dose (MRHD) based on area under the curve (AUC)], or at the same dose to rabbits (approximately 0.1 times and 1 time, respectively, the clinical exposures at the MRHD based on AUC), there were no drug-related malformations

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Hyperammonemia induces neuroinflammation that contributes to cognitive impairment in rats with hepatic encephalopathy

However, those numbers arent high enough for a Type 2 diabetes diagnosis, which Aetna requires for Ozempic coverage

Because of these concerns, it is essential for clinicians to screen for eating disorders before prescribing GLP-1RAs in individuals with overweight or obesity