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doi: 10.1038/s41392-023-01673-4 192 PeiselerMSchwabeRHampeJKubesPHeikenwlderMTackeF

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NAC in very high doses (above 1800mg daily) can theoretically affect cysteine metabolism and insulin signalling, which may be relevant for diabetic patients on tirzepatide, but this is uncommon at standard supplementation levels

[Google Scholar] 12.Crotty Alexander LE, Ware LB, Calfee CS, Callahan SJ, Eissenberg T, Farver C, Goniewicz ML, Jaspers I, Kheradmand F, King TE Jr, Meyer NJ, Mikheev VB, Shields PG, Shihadeh A, Strongin R, and Tarran R