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(1997) The mitochondrial carnitine palmitoyltransferase system from concept to molecular analysis European Journal of Biochemistry, 244(1):1-14

Preserving it maintains a higher calorie burn at rest, which directly supports long-term weight maintenance after the medication is discontinued

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Without specific steps to protect muscle eating enough protein and doing resistance exercise the body has no strong signal to preserve its lean mass during rapid weight loss

[106] However, functional consequences on ME or AP GLP-1/GLP-1R signaling activation are remaining controversial at the current stage