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Wills JW, Long AS, Johnson GE et al (2016b) Empirical analysis of BMD metrics in genetic toxicology part II: in vivo potency comparisons to promote reductions in the use of experimental animals for genetic toxicity assessment

Vet Med Sci

Injections require a clinic visit and may not suit patients with needle phobia or scheduling constraints

Intercurrent illnesses or medication changes (including addition of sedating medications or unavailability of regular symptomatic AD medications): This estimand will be analysed in participants who undergo follow-up RBANS assessment at 180 days (+0, 10 days) and who have taken at least 80% of the study medication, and where there have been no intercurrent events blindly adjudicated as affecting cognition (principal stratum strategy) Secondary estimand epigenetic change 1

Different types of drugs are used to prevent repeated attacks and will subsequently reduce the levels of serum uric acid.