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Restoration of Mecp2 expression in GABAergic neurons is sufficient to rescue multiple disease features in a mouse model of Rett syndrome

Additionally, the upregulation of inflammation-related genes, such as IL-6 and TNF-, is associated with the pathological state of depression, suggesting that immune responses play a critical role in its pathogenesis [365, 366]

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doi: 10.3390/ijms26125823 370 LiaoJ-FChengY-FYouS-TKuoW-CHuangC-WChiouJ-Jet al

Models based on mice, rats, rabbits, goats, and dogs with experimentally induced IVD degeneration have often been used [20], but these animals, with the exception of dogs, do not spontaneously develop IVD degeneration and disease