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As with other GLP-1 receptor medications, theoretical risks include gallbladder disease and, based on animal studies, potential concerns regarding medullary thyroid carcinoma in susceptible individuals

In our experiments, the concentration of CB-839 needed for effective, functional glutaminase inhibition varied from 10 nM to 1 M, and the antiproliferative IC 50 was determined as 0.41 M for the HG-3 cell line and 66.2 M for the MEC-1 cell line

equina adult worms, MCF-7 human breast cancer, and Huh-7 hepatoma cells, possibly corresponding to Glucose-6-phosphate dehydrogenase (G6PD), and HSP-70 respectively [81]

doi: 10.18632/aging.v12i13 70 TangDChenXKangRKroemerG