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Many studies have further demonstrated that abiotic/abiotic stress factors such as heavy metal, drought, water, heat, cellular H 2 O 2 level, oxidative state of the cell could increase the expression of APX genes to either suppress or eliminate the stressors (Ishikawa and Shigeoka, 2008

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5.1 Natural antioxidant defenses in sperm The body inherently generates antioxidant enzymes and non-enzymatic molecules to neutralize ROS and shield cells from oxidative damage

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