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Mice were anesthetized with isoflurane and fixed in prone position

Rifabutin therapy is often used as second-,third -, or fourth-line therapy, but it carries the risk of bone marrow suppression and resistance to Mycobacterium (Gisbert, 2020)

Going 5 days one week and 10 days the next creates fluctuating blood levels that can worsen side effects and reduce effectiveness

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PMID: 28035768