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"Sermorelin: A better approach to management of adult-onset growth hormone insufficiency?" Clinical Interventions in Aging, vol

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(2018) 115:E29609

This article will specifically discuss the pathways of estrogen metabolism, what these pathways represent in clinical practice and how to identify and, subsequently, mitigate the risks associated with developing estrogen-sensitive breast, uterine and prostate cancers in disease prevention

While statistically significant, this generally falls below the clinical significance threshold