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This is precisely why the titration protocol calls for a dose increase at week five

Patients are advised to inject the medicine once a week into the thigh, abdomen, or upper arm

Your provider can assess whether increasing to the next dose level is appropriate based on your tolerance, weight loss trajectory, and overall health status

Its also worth noting that the design of the Wegovy pen makes it so that most of the needle is hidden

The most commonly reported injection site symptoms include: Erythema and warmth transient redness and increased temperature at the injection location Pruritus localized itching that generally resolves within hours to days Induration firm swelling or hardness of subcutaneous tissue Bruising ecchymosis from capillary disruption during injection Pain or tenderness mild discomfort that typically diminishes rapidly While generalized skin sensitivity is not among the most common adverse effects, the FDA labels for both Mounjaro and Zepbound include warnings about the potential for serious hypersensitivity reactions, including anaphylaxis and angioedema, though these are rare