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Once dosage goes up, safety naturally becomes the next concern

Deletion of hepatocyte-specific DPP4 in these aged mice did not affect glucose tolerance as only whole-body deletion of DPP4 increased systemic active GLP-1 and led to reduced blood glucose excursion during oral glucose tolerance test (Supplemental Figure 3, A and B), consistent with previous work (22, 23)

Any references to obesity, glucose regulation, adiposity, liver function, or related biological outcomes are for research context only and must not be interpreted as medical, therapeutic, or clinical claims

The renal pelvis was cannulated with a 32 G triple-lumen catheter (ReCathCo, Allison Park, PA) via the ureter for intrapelvic perfusion and withdrawal of infusate and monitoring of pelvic pressure

Understanding how they work and which conditions they may support can help you determine which option may be most appropriate for your goals