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161,162 The 2-oxoglutarate receptor 1 or GPR99 is a novel receptor for CysLT E4, and its activation increases vascular permeability independent of the CysLTR1/CysLTR2 pathway

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In SURPASS-2, severe hypoglycemia (requiring third-party assistance) occurred in fewer than 0.6% of tirzepatide-treated participants not on sulfonylureas or insulin, mechanistically expected given the glucose-dependent clamp