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The primary endpoint was area under the cagrilintide plasma concentration curve from time zero extrapolated to infinity (AUC 0 ) from baseline (day 1) to day 36 (renal impairment study) or day 39 (hepatic impairment study)

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At least 10,000 cells per sample were analyzed in duplicates and classified into PMN and PBMC based on size and granularity by flow cytometry (FACSCantoII, BD Biosciences, San Jose, USA, Supplementary Figures 1A, D )