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Some patients report a temporary increase in fatigue or mild headache in the first few days, which resolves without intervention

Although challenges such as limited bioavailability and safety concerns continue to impede clinical translation, these limitations may be addressed through the optimization of delivery strategies, rigorous pharmacokinetic and toxicological assessments, mechanism-driven in vitro , in vivo , ex vivo studies, and well-designed clinical trials

ICC, intraclass correlation coefficient

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