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In one-carbon metabolism, cognitively improved patients showed increased cystathionine and decreased 2-hydroxybutyrate and 2-aminobutyrate ( Figure 5A , gray box)

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As part of this trial, we acquired proton MR spectroscopy ( 1 H-MRS) data at pretreatment and ~ 8-weeks posttreatment in a subsample of ( n = 44) participants to evaluate whether NAC significantly affects frontal glutamate levels (i.e., represented by Glx, glutamate + glutamine), with exploratory evaluation of GABA and glutathione levels, and whether NAC-related changes in neurometabolite levels correspond to decreased drinking and/or PTSD symptoms, in people with PTSD + AUD

doi: 10.3390/nu5041417 82

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