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The first SSRI, the first statin, the first PD-1 inhibitor, each one shocked the field with effect sizes that reset expectations, then, over the following decade, slowly revealed the limitations that the next generation was built to fix

doi: 10.1001/jama.280.7.605 [DOI] [PubMed] [Google Scholar] 40.Michels KB, Manson JE

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