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(2003) Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice Biogerontology, 4(4):193-202

The fastest weight loss velocity occurs during the titration phase, roughly months 3 through 6, when dose escalation is most active

By contrast, pharmacological GLP-1 receptor (GLP-1R) signaling achieved through activation by exendin-4 treatment has been shown to increase crypt number in the proximal intestine and colon, leading to increased intestinal circumference and length 15,18

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Each component was subsequently analyzed as an individual secondary outcome