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Vitamin B 12 deficiency also has been linked to psychiatric disorders, including impaired memory, irritability, depression, dementia and, rarely, psychosis

(Figure 5A) illustrates the key components of the pathogenesis of stress-related anxiety disorders, including neuroinflammation, oxidative stress, mitochondrial dysfunction, reduced neuroplasticity, abnormalities in neuronal circuits and neurotransmitter levels, aberrations in cerebral blood flow, impaired LHPA axis function, and abnormalities in the gutbrain and liverbrain axes

Kiewiet, J

combining two compounds that have never been studied together compounds that risk considerably

doi: 10.1097/HEP.0000000000000004, 95