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The resulting crude peptide is then cleaved from the resin, deprotected, and subjected to multistep purification (chromatography, crystallization) to remove byproducts, protecting groups, and residual solvent ( [20] )
OFP-G6PD5.4 accumulated evenly at the ER but also in focal ER sites, independent of the additional presence of PGL2 (for single channel images, refer to Supplementary Figure S7)
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Growing awareness of the long-term complications of uncontrolled diabetes, like neuropathy and cardiovascular disease, is also a critical aspect which further drives the demand for GLP-1 analogues
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