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Excess glucocorticoid exposure suppresses GH secretion mainly through the increase in hypothalamic somatostatin tone, whereas low cortisol levels causes relative GHD that is reversible by glucocorticoid therapy (Giustinas effect) ( Figure 5 ) (104)

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Vitamin E Supplementation : Vitamin E supplementation, like that provided by the production of glutathione, also provides antioxidant properties to dogs