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This intricate network provides insights into the potential therapeutic impact of GLP-1-RA in PCa

Studies have demonstrated that decreased levels of NAD+ are associated with diseases such as Alzheimer's and Parkinson's disease, and boosting NAD levels may offer some benefit

It is a selective estrogen receptor modulator (SERM) that primarily works by blocking estrogen receptors in the brain, which in turn stimulates the production of testosterone

Brierley DI, Holt MK, Singh A et al (2021) Central and peripheral GLP-1 systems independently suppress eating

Interestingly, unlike other MAPKs, such as ERK1/2 and JNK1/2, it has been shown that p38 phosphorylates NRF2 and promotes its association with KEAP1, thereby preventing its nuclear translocation