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Mayo Clinic Proceedings, 93 (4), 467487

If you have high cortisol, you could experience some of the following symptoms of chronic stress over time: High blood pressure Increased blood sugar levels Reduced bone density Metabolic syndrome Immune system suppression Depression Anxiety Digestive issues Infertility Irregular periods Acne Easy skin bruising Chronic fatigue Increased appetite Poor sleep quality Increased stomach acid Irritability and mood swings How To Lower Cortisol Levels With Supplements While there are lifestyle changes you can practice to reduce stress, such as avoiding your stress triggers, practicing mindfulness, or learning stress management, supplements can give your body the help it needs to manage high cortisol levels