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An increasing concentration of unlabeled GLP-2(133) or teduglutide (ranging from 0.1 nM to 1 M) followed by a fixed concentration of [ 125 I]GLP-2(133, M10Y) (1015 pM) was added to the cells and incubated for 4 h at 4 C

53 McBrideP

Transcriptional networks regulating the costamere, sarcomere, and other cytoskeletal structures in striated muscle

We propose that curcumin exerts its broad therapeutic effects via a unified inflammationoxidative stress axis, primarily by inhibiting NF-B and NLRP3 activation, reducing ROS and pro-inflammatory cytokines (TNF-, IL-1/18), as seen across models of depression, metabolic disorders, and neurodegeneration

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