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97 One underpowered trial that included hydroxyzine and PPS-hydroxyzine arms also reported no statistically significant differences on any measured parameter at six months between PPS (100 mg three times daily) and placebo patients with statistically similar proportions reporting improvement (PPS 28% versus placebo 13%)

The 5-on/2-off schedule emulates natural GH pulsatility rhythms and reduces receptor desensitization during longer overall cycle windows

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Reversion: If treatments are discontinued, melanin production gradually returns to normal levels, potentially reversing whitening effects over time