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At the same time, the velocity of -lactamase hydrolysis (Vh, nmol/mg per second) of ampicillin increased approximately 2-fold and the rate of drug efflux (Ve, nmol/mg per second) increased 30%

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Nanoparticles exploit the EPR effect to accumulate in inflamed joints, achieving 2 - 3-fold higher concentrations than in healthy tissues (10)

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