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In conclusion, non-pharmacological therapies that focus on controlling the etiology of liver disease, improving nutrition, increasing muscle mass, mitigating triggers and risk factors, and enhancing coping mechanisms are significantly more effective in combating fatigue in cirrhosis compared to pharmacological treatments (Figure 2) (4, 9)

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Here, we show that the modulation of sperm capacitation, to the extent that it recapitulates in vivo events, can contribute to the preimplantation development of high-quality embryos and, ultimately, to the birth of a healthy offspring