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Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomized controlled trial

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Cycle or Stack GLP-1 Therapies Taper and re-titrate periodically (under supervision) Consider transitioning from one GLP-1 to another, for example from semaglutide to tirzepatide (or vice versa) Use metabolic support (e.g., SLM+ ) with GLP-1 therapy and during off-phases or dose reductions 3

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To address the imbalance between the four treatment groups, 1:1:1:1 propensity score matching (PSM) was performed