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The macules are larger and appear more pigmented than ephelides

These actions improve the chloride ion currents mediated by GABA ( (2) Selectively inhibits voltage-dependent Na + channels, which reduces or stops the release of neurotransmitters and vasoactive peptides, inhibits action potential propagation, and lessens focal discharges ( (3) It minimizes sustained membrane depolarization, raises the threshold for migraines, inhibits the release of CGRP and glutamate from the trigeminal vascular nerve endings, blocks high-voltage activated Ca 2+ channels, and reduces or prevents the release of neurotransmitters and vasoactive peptides ( (4) Reduces glutamate release as well as discharges by antagonistically binding to the AMPA/kainate receptors while having no discernible effect on the N-methyl-D-aspartic acid receptor subtypes ( (5) Reduces the levels of excitatory neurotransmitters and increases the transmission of inhibitory neurotransmitters by inhibiting carbonic anhydrase (CA), especially CA II and CA IV (White, 2005)

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