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What the Clinical Trials Say Retatrutide has been studied in several clinical trials

(linked) Jastreboff AM, et al

The combination of weight-loss medicine and lifestyle changes can lead to greater weight loss than lifestyle changes alone do

Because the drug binds to the GLP-1 receptors in the body, Ozempic promotes the secretion of insulin, reduces glucagon production (which lowers blood sugar), and slows down stomach emptying, leading to a decreased appetite