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However, weight loss itself often improves vasomotor symptoms in some women, and reducing insulin resistance (which GLP-1 does) may ease overall metabolic stress

Its a consequence of excessive caloric restriction, inadequate protein intake, and lack of resistance training

It belongs to a novel class of drugs known as triple agonists, meaning it simultaneously activates three hormone receptors: the glucagon-like peptide-1 (GLP-1) receptor, the glucose-dependent insulinotropic polypeptide (GIP) receptor, and the glucagon receptor

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For the full scientific overview, see What Is Retatrutide