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This mechanism helps in reducing the burden of toxic substances and supporting the liver's natural detoxification pathways

Structural features and signaling mechanisms of GPER Structural characteristics of GPER GPER, initially called G protein-coupled receptor 30 (GPR30) in the 1990 s [9, 10], mediates the nongenomic effects of 17-estradiol via mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase 1/2 (ERK-1/2)

Wakabayashi T, Yamaguchi K, Matsui K, Sano T, Kubota T, Hashimoto T, Mano A, Yamada K, Matsuo Y, Kubota N, Kadowaki T, Iwatsubo T (2019) Differential effects of diet- and genetically-induced brain insulin resistance on amyloid pathology in a mouse model of Alzheimers disease

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